Hydrochloric Acid → HCID 19032882, compound

HRID 266320Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH:12]([CH2:27][N:28]2[CH:32]=[CH:31][N:30]=[CH:29]2)[C:13]([NH:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23]([O:25]C)=[O:24])=[O:14])(=[O:10])=[O:9])=[CH:4][CH:3]=1.Cl>>[ClH:1].[C:23]([CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][NH:15][C:13](=[O:14])[CH:12]([NH:11][S:8]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)(=[O:10])=[O:9])[CH2:27][N:28]1[CH:32]=[CH:31][N:30]=[CH:29]1)([OH:25])=[O:24]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 19032779HCID 19032779, compound

Product 1

HCID 19032882HCID 19032882, compoundYield 185.9%

Procedure

The procedure described in Example 92 was repeated, except that (RS)-2-(4-chlorobenzenesulfonylamino)-3-(1H-imidazol-1-yl)-N-(7-methoxycarbonylheptyl)propanamide (25.6 mg) was hydrolyzed, and then reacted with HCl to obtain (RS)-N-(7-carboxyheptyl)-2-(4-chlorobenzenesulfonylamino)-3-(1H-imidazol-1-yl)propanamide hydrochloride (24.9 mg).

Sources & evidence

ORD record: ord-5f9613375b984adb9ddc1d5f09b41ce9
Source dataset: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05650428

Reaction notes

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