3-Hydroxypyridine → HCID 19032754, compound

HRID 266329Notes

Reaction equation

[CH2:1]([O:3][C:4]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14](=[O:33])[CH:15]([NH:22][S:23]([C:26]2[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=2)(=[O:25])=[O:24])[CH2:16][O:17]S(C)(=O)=O)=[CH:9][CH:8]=1)=[O:5])[CH3:2].O[C:35]1[CH:36]=[N:37][CH:38]=[CH:39][CH:40]=1>>[CH2:1]([O:3][C:4]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14](=[O:33])[CH:15]([NH:22][S:23]([C:26]2[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=2)(=[O:25])=[O:24])[CH2:16][O:17][C:35]2[CH:36]=[N:37][CH:38]=[CH:39][CH:40]=2)=[CH:9][CH:8]=1)=[O:5])[CH3:2]

Participants

Reactant 2

HCID 79713-Hydroxypyridine

HCID 19032872HCID 19032872, compound

Product 1

HCID 19032754HCID 19032754, compound

Procedure

The procedure described in Example 105 was repeated, except that (RS)-N-(4-(ethoxycarbonylmethyl)phenyl)-2-(4-fluorobenzenesulfonylamino)-3-methanesulfonyloxypropanamide (250 mg) was reacted with 3-hydroxypyridine to obtain (RS)-N-(4-(ethoxycarbonylmethyl)phenyl)-2-(4-fluorobenzenesulfonylamino)-3-(pyridin-3-yloxy)propanamide (112.6 mg).

Sources & evidence

ORD record: ord-35adc9cd158e422cbaeca6f97ce0acad
Source dataset: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05650428

Reaction notes

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