Hydrochloric Acid → HCID 19032892, compound

HRID 266334Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH:12]([CH2:23][O:24][C:25]2[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=2)[C:13]([NH:15][CH2:16][CH2:17][CH2:18][C:19]([O:21]C)=[O:20])=[O:14])(=[O:10])=[O:9])=[CH:4][CH:3]=1.Cl>>[ClH:1].[C:19]([CH2:18][CH2:17][CH2:16][NH:15][C:13](=[O:14])[CH:12]([NH:11][S:8]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)(=[O:10])=[O:9])[CH2:23][O:24][C:25]1[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=1)([OH:21])=[O:20]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 19032721HCID 19032721, compound

Product 1

HCID 19032892HCID 19032892, compoundYield 151.1%

Procedure

The procedure described in Example 115 was repeated, except that (RS)-2-(4-chlorobenzenesulfonylamino)-N-(3-methoxycarbonylpropyl)-3-(pyridin-3-yloxy)propanamide (39.6 mg) was hydrolyzed, and then reacted with HCl to obtain (RS)-N-(3-carboxypropyl)-2-(4-chlorobenzenesulfonylamino)-3-(pyridin-3-yloxy)propanamide hydrochloride (31.4 mg).

Sources & evidence

ORD record: ord-364a307c838b4372a5bda6489b94a3a3
Source dataset: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05650428

Reaction notes

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