4-Chlorophenol → HCID 19032722, compound

HRID 266343Notes

Reaction equation

[CH2:1]([O:3][C:4]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14](=[O:33])[CH:15]([NH:22][S:23]([C:26]2[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=2)(=[O:25])=[O:24])[CH2:16][O:17]S(C)(=O)=O)=[CH:9][CH:8]=1)=[O:5])[CH3:2].[Cl:34][C:35]1[CH:40]=[CH:39][C:38](O)=[CH:37][CH:36]=1>>[Cl:34][C:35]1[CH:40]=[CH:39][C:38]([O:17][CH2:16][CH:15]([NH:22][S:23]([C:26]2[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=2)(=[O:25])=[O:24])[C:14]([NH:13][C:10]2[CH:11]=[CH:12][C:7]([CH2:6][C:4]([O:3][CH2:1][CH3:2])=[O:5])=[CH:8][CH:9]=2)=[O:33])=[CH:37][CH:36]=1

Participants

Reactant 2

HCID 46844-Chlorophenol

HCID 19032872HCID 19032872, compound

Product 1

HCID 19032722HCID 19032722, compoundYield 74%

Procedure

The procedure described in Example 125 was repeated, except that (RS)-N-(4-(ethoxycarbonylmethyl)phenyl)-2-(4-fluorobenzenesulfonylamino)-3-methanesulfonyloxypropanamide (300 mg) was reacted with 4-chlorophenol (153 mg) to obtain (RS)-3-(4-chlorophenoxy)-N-(4-(ethoxycarbonylmethyl)phenyl)-2-(4-fluorobenzenesulfonylamino)propanamide (236.25 mg).

Sources & evidence

ORD record: ord-b7903620ce684735be576bb539f84381
Source dataset: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05650428

Reaction notes

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