HCID 54071153, compound → HCID 53636025, compound

HRID 266410Notes

Reaction equation

HRID 266410 reaction equation
[C:1]([O:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][C:20]([C:22]2[CH:30]=[CH:29][C:28]([C:31]([O:33][C:34]3[CH:39]=[CH:38][C:37]([O:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][O:47][C:48](=[O:51])[CH:49]=[CH2:50])=[CH:36][CH:35]=3)=[O:32])=[CH:27][C:23]=2[C:24]([OH:26])=[O:25])=[O:21])=[CH:15][CH:14]=1)(=[O:4])[CH:2]=[CH2:3].[NH2:52][C:53]1[CH:58]=[C:57]([O:59][C@H:60]([CH2:62][CH2:63][CH2:64][CH2:65][CH2:66][CH3:67])[CH3:61])[C:56]([N+:68]([O-:70])=[O:69])=[CH:55][C:54]=1[C:71]1[CH:89]=[CH:88][C:74]([C:75]([O:77][C:78]2[CH:87]=[CH:86][C:81]([O:82][CH:83](O)[CH3:84])=[CH:80][CH:79]=2)=[O:76])=[CH:73][CH:72]=1>CN(C)C1C=CN=CC=1.ClCCl>[C:1]([O:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:14]=[CH:15][C:16]([O:19][C:20]([C:22]2[CH:30]=[CH:29][C:28]([C:31]([O:33][C:34]3[CH:35]=[CH:36][C:37]([O:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][O:47][C:48](=[O:51])[CH:49]=[CH2:50])=[CH:38][CH:39]=3)=[O:32])=[CH:27][C:23]=2[C:24]([O:26][CH2:84][CH2:83][O:82][C:81]2[CH:80]=[CH:79][C:78]([O:77][C:75](=[O:76])[C:74]3[CH:73]=[CH:72][C:71]([C:54]4[CH:55]=[C:56]([N+:68]([O-:70])=[O:69])[C:57]([O:59][C@H:60]([CH2:62][CH2:63][CH2:64][CH2:65][CH2:66][CH3:67])[CH3:61])=[CH:58][C:53]=4[NH2:52])=[CH:89][CH:88]=3)=[CH:87][CH:86]=2)=[O:25])=[O:21])=[CH:17][CH:18]=1)(=[O:4])[CH:2]=[CH2:3]

Participants

5

Reactant 2

HCID 54071153HCID 54071153, compoundHCID 70271152HCID 70271152, compound

Product 1

HCID 53636025HCID 53636025, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 6344DichloromethaneSolvent

Procedure

0.6 g of 2,5-bis (4-[6-acryloyloxyhexyloxy]phenylcarboxy)benzoic acid and 0.4 g of (4-[4-(2-amino-5-nitro-4-[(S)-2-octyloxy]phenyl)benzoyloxy]phenoxy)ethanol, 0.04 g of 4-dimethylaminopyridine, 0.2 g N,N'-dicyclodicyclohexyldicarbodiimide and 20 ml of dichloromethane are reacted in an analogous manner to Example 1 to give (4-[4-(2-amino-5-nitro-4-[(S)-2-octyloxy]-phenyl)benzoyloxy]phenoxy)ethyl 2,5-bis (4-[6-acryloyloxyhexyloxy]phenylcarboxy)benzoate.

Sources & evidence

ORD record
ord-99bb72912ef44335a6e09b2e32fb7b46
Source dataset
uspto-grants-1997_07
Patent number
US05650534

Reaction notes

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