HCID 21263535, compound → HCID 70271152, compound

HRID 266411Notes

Reaction equation

HRID 266411 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([O:8][C@H:9]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[CH3:10])[C:5]([N+:17]([O-:19])=[O:18])=[CH:4][C:3]=1[C:20]1[CH:28]=[CH:27][C:23]([C:24]([OH:26])=[O:25])=[CH:22][CH:21]=1.O[C:30]1[CH:39]=[CH:38][C:33]([O:34][CH:35]([OH:37])[CH3:36])=[CH:32][CH:31]=1>CN(C)C1C=CN=CC=1.ClCCl>[NH2:1][C:2]1[CH:7]=[C:6]([O:8][C@H:9]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[CH3:10])[C:5]([N+:17]([O-:19])=[O:18])=[CH:4][C:3]=1[C:20]1[CH:28]=[CH:27][C:23]([C:24]([O:26][C:30]2[CH:39]=[CH:38][C:33]([O:34][CH:35]([OH:37])[CH3:36])=[CH:32][CH:31]=2)=[O:25])=[CH:22][CH:21]=1

Participants

5

Reactant 2

HCID 21263535HCID 21263535, compoundHCID 86751110HCID 86751110, compound

Product 1

HCID 70271152HCID 70271152, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 6344DichloromethaneSolvent

Procedure

0.6 g of 4-[4-(2-amino-5-nitro-4-[(S)-2-octyloxy]phenyl)benzoic acid and 0.2 g of (4-hydroxyphenoxy)ethanol, 0.04 g of 4-dimethylaminopyridine, 0.4 g of N,N'-dicyclodicyclohexyldicarbodimide and 50 ml of dichloromethane are reacted in an analogous manner to Example 1 to give 0.4 g of (4-[4-(2-amino-5-nitro-4-[(S)-2-octyloxy]phenyl)benzoyloxy]phenoxy)ethanol.

Sources & evidence

ORD record
ord-6d88c90eb5a74c8b9462d58f2462dfa3
Source dataset
uspto-grants-1997_07
Patent number
US05650534

Reaction notes

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