Hydrochloric Acid → HCID 88386648, compound

HRID 266426Notes

Reaction equation

HRID 266426 reaction equation
C[O:2][C:3](=[O:21])/[C:4](/[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[O:13][C:14]1[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=1)=[N:5]/[OH:6].CO.[OH-].[Na+].Cl>O>[OH:6]/[N:5]=[C:4](\[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[O:13][C:14]1[CH:15]=[CH:16][C:17]([CH3:20])=[CH:18][CH:19]=1)/[C:3]([OH:21])=[O:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 88361076HCID 88361076, compound

Product 1

HCID 88386648HCID 88386648, compoundYield 94.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To E-α-hydroxyimino-2-(4-methylphenoxy)phenylacetic acid methyl ester (1.00 g, 0.0035 mole) were added methanol (3.5 ml), water (3.5 ml), sodium hydroxide (0.31 g, 0.0077 mole) and the mixture was heated under reflux for one hour. After cooling to room temperature, the resultant was adjusted to pH 1 with 5% of hydrochloric acid. After stirring at room temperature, the crystals were filtered off and washed with water to obtain colorless crystals of E-α-hydroxyimino-2-(4-methylphenoxy)phenylacetic acid (0.90 g, yield: 94.7%).

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for one hour
  3. filtrationthe crystals were filtered off
  4. washwashed with water

Sources & evidence

ORD record
ord-1ffa65cec6d04933ba653e88fdb1b872
Source dataset
uspto-grants-1997_07
Patent number
US05650539

Reaction notes

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