HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl acetate hexane → HCID 67596817, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl acetate hexane | HCID 21226206 | — |
| Reactant | 2-Chloromethyl-4-ethyl-5,7-dimethoxy-6-methylsaccharin | HCID 70052343 | — |
| Reactant | HCID 178527989 | HCID 178527989 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 67596817 | HCID 67596817 | 76% |
Reaction Steps
By the method of Example 44 condensation of 2-chloromethyl-4-ethyl-5,7-dimethoxy-6-methylsaccharin (0.17 g) and 1-phenyltetrazol-5-thiol sodium salt (0.084 g) in dimethylformamide (4 mL) and purification of the product by flash column chromatography on silica gel using hexane-ethyl acetate (75:25) as eluant afforded 2-(1-phenyltetrazol-5-yl)thiomethyl-4-ethyl-5,7-dimethoxy-6-methylsaccharin, 0.15 g, 76% yield, mp 44°-46° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05650422 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-5d7e07e8273343f19c6ecff4004e9a95 |
| Source note | uspto-grants-1997_07 |