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HRID266481

反应详情

EQUATION

反应方程式

HRID 266481 的结构方程式

REACTANTS

反应物

3
结构：CCCCCC.CCOC(C)=O
HCID21226206

未命名化合物

结构：CCc1c(OC)c(C)c(OC)c2c1C(=O)N(CCl)S2(=O)=O
HCID70052343

未命名化合物

结构：Sc1nnnn1-c1ccccc1.[Na]
HCID178527989

未命名化合物

PRODUCTS

生成物

1
结构：CCc1c(OC)c(C)c(OC)c2c1C(=O)N(CSc1nnnn1-c1ccccc1)S2(=O)=O
HCID67596817

未命名化合物

收率 76%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

By the method of Example 44 condensation of 2-chloromethyl-4-ethyl-5,7-dimethoxy-6-methylsaccharin (0.17 g) and 1-phenyltetrazol-5-thiol sodium salt (0.084 g) in dimethylformamide (4 mL) and purification of the product by flash column chromatography on silica gel using hexane-ethyl acetate (75:25) as eluant afforded 2-(1-phenyltetrazol-5-yl)thiomethyl-4-ethyl-5,7-dimethoxy-6-methylsaccharin, 0.15 g, 76% yield, mp 44°-46° C.