Hydrochloric Acid → HCID 53897031, compound

HRID 266572Notes

Reaction equation

HRID 266572 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9]CC(C)(C)N=2)=[C:4]([S:15][CH3:16])[C:3]=1[O:17][CH3:18].Cl.[OH2:20]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([OH:9])=[O:20])=[C:4]([S:15][CH3:16])[C:3]=1[O:17][CH3:18]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 54263053HCID 54263053, compound

Product 1

HCID 53897031HCID 53897031, compound

Procedure

A mixture of 2-[4-chloro-3-methoxy-2-(methylsulphenyl)-phenyl]-4,4-dimethyloxazoline (9.0 g) and hydrochloric acid (5M) was stirred and heated at reflux for 5 hours. After cooling the mixture was diluted with water and extracted with dichloromethane. It was dried (MgSO4), filtered and the filtrate was evaporated to dryness to give 4-chloro-3-methoxy-2-(methylsulphenyl) benzoic acid as a white solid, m.p. 98°-99° C.

Workup

  1. temperatureheated
  2. temperatureat reflux for 5 hours
  3. temperatureAfter cooling the mixture
  4. extractionextracted with dichloromethane
  5. dry with materialIt was dried (MgSO4)
  6. filtrationfiltered
  7. customthe filtrate was evaporated to dryness

Sources & evidence

ORD record
ord-df22f392b3354c1cb729d89b99792499
Source dataset
uspto-grants-1997_07
Patent number
US05650533

Reaction notes

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