Hydrochloric Acid → (R)-8-Fluoro-3-(N-3-pentyl-N-n-propylamino)-5-trifluoromethanesulfonyloxychroman hydrochloride

HRID 266644Notes

Reaction equation

HRID 266644 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:21][S:22]([C:25]([F:28])([F:27])[F:26])(=[O:24])=[O:23])=[C:6]2[C:11]=1[O:10][CH2:9][C@H:8]([N:12]([CH:16]([CH2:19][CH3:20])[CH2:17][CH3:18])[CH2:13][CH2:14][CH3:15])[CH2:7]2.[ClH:29]>CCOCC>[ClH:29].[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:21][S:22]([C:25]([F:27])([F:26])[F:28])(=[O:23])=[O:24])=[C:6]2[C:11]=1[O:10][CH2:9][C@H:8]([N:12]([CH:16]([CH2:19][CH3:20])[CH2:17][CH3:18])[CH2:13][CH2:14][CH3:15])[CH2:7]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54407297(R)-8-fluoro-3-(N-3-pentyl-N-n-propylamino)-5-trifluoromethanesulfonyloxychroman

Product 1

HCID 88370683(R)-8-Fluoro-3-(N-3-pentyl-N-n-propylamino)-5-trifluoromethanesulfonyloxychroman hydrochloride

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

(R)-8-Fluoro-3-(N-3-pentyl-N-n-propylamino)-5-trifluoromethanesulfonyloxychroman (100 mg, 0.23 mmol) was dissolved in ether. HCl in ether was added to precipitate the HCl-salt, and gave after drying 110 mg of (R)-8-fluoro-3-(N-3-pentyl-N-n-propylamino)-5-trifluoromethanesulfonyloxychroman hydrochloride as a white powder. Mp. 45°-60° C. (sinters).

Workup

  1. customto precipitate the HCl-salt
  2. customgave
  3. dry with materialafter drying 110 mg of (R)-8-fluoro-3-(N-3-pentyl-N-n-propylamino)-5-trifluoromethanesulfonyloxychroman hydrochloride as a white powder

Sources & evidence

ORD record
ord-135b054ca91c4f45b44689b3d055fb5c
Source dataset
uspto-grants-1997_07
Patent number
US05650524

Reaction notes

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