Hydrochloric Acid → HCID 86751116, compound

HRID 266654Notes

Reaction equation

HRID 266654 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:5]=[CH:6][C:7]=1[F:8].[Cl-].[Al+3].[Cl-].[Cl-].[C:19](Cl)(=[O:21])[CH3:20].Cl>ClCCl>[F:1][CH:2]1[C:7]([F:8])([C:19](=[O:21])[CH3:20])[CH:6]=[CH:5][C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:3]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 6367Acetyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 130223903,4-Difluoro-1,1'-biphenyl

Product 1

HCID 86751116HCID 86751116, compoundYield 106.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
20 °C

Procedure

To one liter of dichloromethane were added 191 g of 3,4-difluorobiphenyl and 160 g of aluminum chloride, and maintaining the temperature to about 20° C., 86 g of acetyl chloride was gradually added dropwise under stirring. After completion of the dropwise addition, stirring was continued for 10 hours, and then 100 ml of hydrochloric acid was added to the mixture and the mixture was stirred well and washed. The mixture was further washed with water and the solvent was removed under reduced pressure. The residue was purified by distillation under reduced pressure (164° C./1 mmHg) to obtain 250 g of 3,4-difluoro-4-acetylbiphenyl.

Workup

  1. additionAfter completion of the dropwise addition
  2. stirringstirring
  3. stirringthe mixture was stirred well
  4. washwashed
  5. washThe mixture was further washed with water
  6. customthe solvent was removed under reduced pressure
  7. distillationThe residue was purified by distillation under reduced pressure (164° C./1 mmHg)

Sources & evidence

ORD record
ord-eed96ee7333841939f221283959eb947
Source dataset
uspto-grants-1997_07
Patent number
US05651919

Reaction notes

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