Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethylene Oxide | HCID 6354 | — |
| Reactant | 4-(N-Propionylaniline)piperidine | HCID 259381 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 10850080 | HCID 10850080 | — |
Reaction Steps
A solution, cooled to 15° C., containing 100 mmol of ethylene oxide in toluene is added slowly to 100 mmol of 4-(N-propionylanilino)piperidine in solution in 100 ml of anhydrous methanol cooled to 15° C. After returning to room temperature and removal of the azeotrope formed by distillation, the expected product is obtained after evaporation to dryness.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05652246 |
|---|
| Source dataset | uspto-grants-1997_07 |
|---|
| ORD ID | ord-0cf41979ba5f46fc9d1a0f479f4905b6 |
|---|
| Source note | uspto-grants-1997_07 |
|---|
