反应详情

Then a solution of 5-nitroindole (1.62 g, 0.01 mol) in 1,2-dichloroethane (50 ml) was added and the mixture heated to reflux for 3 h. After cooling the mixture was poured onto iced water, the precipitate filtered off and washed with water. Thereupon the residue was chromatographed over silica gel using benzene/ethylacetate as eluant. Thus pure title compound was obtained in 80% yield (1.52 g).

1. temperaturethe mixture heated
2. temperatureto reflux for 3 h
3. temperatureAfter cooling the mixture
4. filtrationthe precipitate filtered off
5. washwashed with water
6. customThereupon the residue was chromatographed over silica gel