反应详情

32.3 g (155 mol) of 3-chloro-4-trifluoromethylbenzaldehyde and 18.0 g (155 mmol) of methyl acetoacetate are dissolved in 200 ml of methylene chloride, and 1.2 ml of piperidine and 1 ml of glacial acetic acid are added. The mixture is heated for 5 hours, using a water separator. It is then washed with water, dried over MgSO4 and concentrated. The product is recrystallized twice from methanol. 25.6 g (54% of theory) of the title compound are obtained.

1. temperatureThe mixture is heated for 5 hours
2. washIt is then washed with water
3. dry with materialdried over MgSO4
4. concentrationconcentrated
5. customThe product is recrystallized twice from methanol