反应详情

A solution of 0.3 g (1.8 mmole) of (S)-(-)-2-nitro-1-(2-oxiranyl-methyl)-1H-imidazole, 0.24 g (5.4 mmole) of 1H-aziridine, and 3.5 mL of 99:1 absolute ethanol:triethylamine is heated at reflux for 10 minutes, cooled, and concentrated. The residue is crystallized from 99:1 absolute ethanol:triethylamine to give product, mp 119.5°-121° C. [α]D25 =-28.7° [c1.15, chloroform].

1. temperatureat reflux for 10 minutes
2. temperaturecooled
3. concentrationconcentrated
4. customThe residue is crystallized from 99:1 absolute ethanol
5. customtriethylamine to give product, mp 119.5°-121° C. [α]D25 =-28.7° [c1.15, chloroform]