Nitric Acid → HCID 19031177, compound

HRID 266791Notes

Reaction equation

HRID 266791 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH2:11][CH2:10][C:8]2=[O:9])[CH2:3][CH2:2]1.S(=O)(=O)(O)O.[N+:23]([O-])([OH:25])=[O:24]>>[N+:23]([C:14]1[CH:13]=[C:12]2[C:17](=[CH:16][CH:15]=1)[N:7]([CH:4]1[CH2:5][CH2:6][NH:1][CH2:2][CH2:3]1)[C:8](=[O:9])[CH2:10][CH2:11]2)([O-:25])=[O:24]

Participants

4

Reactant 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 107281851-(piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one

Product 1

HCID 19031177HCID 19031177, compound

Procedure

1-(4-Piperidinyl)-3,4-dihydrocarbostyril (0.2 g) is added to conc. sulfuric acid (5 ml) and thereto is added fuming nitric acid (0.1 ml) under ice cooling. The mixture is stirred at room temperature for 30 minutes, and then the reaction mixture is poured into ice-water. The mixture is basified and extracted with dichloromethane. The solvent is concentrated to give 6-nitro-1-(4-piperidinyl)-3,4-dihydrocarbostyril (0.2 g).

Workup

  1. extractionextracted with dichloromethane
  2. concentrationThe solvent is concentrated

Sources & evidence

ORD record
ord-d309b23a920641b49a78afab88e472f8
Source dataset
uspto-grants-1997_07
Patent number
US05652247

Reaction notes

Loading…