HuagongsheHuagongshe Chemistry Print Report · For research reference only
Spiro[chroman-2,4'-piperidine] → N-[1(R)-[(3,4-dihydro-spiro[2H-1-benzopyran-2,4'-piperidin]-1'-yl)carbonyl]-2-(indol-3-yl)ethyl]-2-[[(1,1-dimethylethyloxy)carbonyl]amino]-2-methylpropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Spiro[chroman-2,4'-piperidine] | HCID 15187049 | — |
| Reactant | (R)-2-(2-((tert-Butoxycarbonyl)amino)-2-methylpropanamido)-3-(1H-indol-3-yl)propanoic acid | HCID 15895387 | — |
| Product | N-[1(R)-[(3,4-dihydro-spiro[2H-1-benzopyran-2,4'-piperidin]-1'-yl)carbonyl]-2-(indol-3-yl)ethyl]-2-[[(1,1-dimethylethyloxy)carbonyl]amino]-2-methylpropanamide | HCID 22862460 | — |
Reaction Steps
This intermediate was prepared from the product of Step A and α(R)-[[2-[[(1,1-dimethylethoxy)carbonyl]amino]-2,2-dimethyl-1-oxoethyl]amino]-1H-indole-3-propanoic acid following standard peptide coupling methods.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05652235 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-fc133c2011e44a9990c77440d620e31c |
| Source note | uspto-grants-1997_07 |