HCID 18913790, compound → HCID 18913799, compound

HRID 266927Notes

Reaction equation

HRID 266927 reaction equation
[CH3:1][O:2][C:3]1[CH:33]=[CH:32][C:31]([N+:34]([O-])=O)=[CH:30][C:4]=1[CH2:5][N:6]1[CH2:17][CH2:16][N:15]([CH2:18][C:19]([OH:21])=[O:20])[CH2:14][CH2:13][N:12]([CH2:22][C:23]([OH:25])=[O:24])[CH2:11][CH2:10][N:9]([CH2:26][C:27]([OH:29])=[O:28])[CH2:8][CH2:7]1>O=[Pt]=O>[CH3:1][O:2][C:3]1[CH:33]=[CH:32][C:31]([NH2:34])=[CH:30][C:4]=1[CH2:5][N:6]1[CH2:7][CH2:8][N:9]([CH2:26][C:27]([OH:29])=[O:28])[CH2:10][CH2:11][N:12]([CH2:22][C:23]([OH:25])=[O:24])[CH2:13][CH2:14][N:15]([CH2:18][C:19]([OH:21])=[O:20])[CH2:16][CH2:17]1

Participants

3

Reactant 1

HCID 18913790HCID 18913790, compound

Product 1

HCID 18913799HCID 18913799, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 345198Adams' catalystCatalyst

Procedure

To a nitrogen purged aqueous (50 ml) solution containing 50 mg of PtO2 was added 50 mg of 1-(2-methoxy-5-nitrobenzyl)-1,4,7,10-tetraazacyclododecane-4,7,10-triacetic acid (prepared by the procedure of Example 23). After hydrogenating in a Parr bomb for one hour, the solution was filtered and the aqueous filtrate freeze-dried to give the aniline derivative as a tan solid (95 percent yield), MF>240° C. dec, and further characterized by:

Workup

  1. customprepared by the procedure of Example 23)
  2. filtrationthe solution was filtered
  3. customthe aqueous filtrate freeze-dried

Sources & evidence

ORD record
ord-8b8985a62c3e44da910395680c306556
Source dataset
uspto-grants-1997_07
Patent number
US05652361

Reaction notes

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