反应详情

A mixture of 26 g of 2,5-dichloro-nitrobenzene, 400 ml of ethanol and 25 ml of ethylamine was refluxed for 24 hours while adding 5 ml of ethylamine at 6 hour intervals and the mixture was cooled and filtered. The orange needles were washed with a small amount of an ethanol-ether mixture and dried over P2O5 under vacuum to obtain 24.4 g (89% yield) of N-ethyl-4-chloro-2-nitro-aniline melting at 90°-91° C.

1. temperaturewas refluxed for 24 hours
2. temperaturethe mixture was cooled
3. filtrationfiltered
4. washThe orange needles were washed with a small amount of an ethanol-ether mixture
5. dry with materialdried over P2O5 under vacuum