反应详情

To a suspension of 1H-imidazole-4-acetic acid methyl ester hydrochloride (1, 7.48, 42.4 mmol) in methylene chloride (200 ml) was added triethylamine (17.7 ml, 127 mmol) and triphenylmethyl bromide (16.4 g, 50.8 mmol) and stirred for 72 h. After this time, reaction mixture was washed with sat. aq. sodium bicarbonate (100 ml) and water (100 ml). The organic layer was evaporated in vacuo and purified by flash chromatography (30-100% ethyl acetate/hexanes gradient elution) to provide 23 as a white solid.

1. customAfter this time, reaction mixture
2. washwas washed with sat. aq. sodium bicarbonate (100 ml) and water (100 ml)
3. customThe organic layer was evaporated in vacuo
4. custompurified by flash chromatography (30-100% ethyl acetate/hexanes gradient elution)