HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-Phenyl-3-t-butyl-5-p-toluenesulfonyloxymethyloxazolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| Reactant | 3-(1,1-Dimethylethyl)-2-phenyloxazolidine-5-methanol | HCID 108810 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 2-Phenyl-3-t-butyl-5-p-toluenesulfonyloxymethyloxazolidine | HCID 12583733 | — |
Reaction Steps
To a solution of dl-2-phenyl-3-t-butyl-5-hydroxymethyloxazolidine (12.05 g.) in triethylamine (120 ml.) 13 is added p-toluenesulfonylchloride (14.5 g.). After 6 days at room temperature the mixture is added to water (500 ml.) and extracted with ether (2×200 ml.). The ether solution is washed with water, dried with anhydrous magnesium sulfate and evaporated to dryness. The residue is recrystallized from hexane to afford 2-phenyl-3-t-butyl-5-p-toluenesulfonyloxymethyloxazolidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04151297 |
| Source dataset | uspto-grants-1979_04 |
| ORD ID | ord-8d9cadbdf09c4fe3a8cb4f6f4140267a |
| Source note | uspto-grants-1979_04 |