Formic Acid → HCID 178440031, compound

HRID 267205Notes

Reaction equation

HRID 267205 reaction equation
[NH2:1][C:2]1[NH:7][CH2:6][C:5]2=[C:8]([CH3:14])[N:9]=[C:10]([CH2:11][CH2:12][CH3:13])[N:4]2[N:3]=1.[CH:15](O)=[O:16]>>[CH3:14][C:8]1[N:9]=[C:10]([CH2:11][CH2:12][CH3:13])[N:4]2[C:5]=1[CH2:6][NH:7][C:2]([NH:1][CH:15]=[O:16])=[N:3]2

Participants

3

Reactant 2

HCID 284Formic AcidHCID 178440032HCID 178440032, compound

Product 1

HCID 178440031HCID 178440031, compound

Procedure

2-Amino-3,4-dihydro-5-methyl-7-propylimidazo[ 5,1-f]-as-triazine (Example 1a) (2.2 g.) in formic acid (50 ml., 99°) was heated under reflux for 24 hours and evaporated under reduced pressure. The residue was stirred with 2N sodium carbonate and the solid was collected and dried and had m.p. 188.5°-190.5°. Its hydrogen maleate salt had m.p. 159°-161° (crystallised from a mixture of methanol and ether).

Workup

  1. temperatureunder reflux for 24 hours
  2. customevaporated under reduced pressure
  3. customthe solid was collected
  4. customdried
  5. customcrystallised from a mixture of methanol and ether)

Sources & evidence

ORD record
ord-a9e5f6de261547f1aad545d221ed73db
Source dataset
uspto-grants-1976_03
Patent number
US03941785

Reaction notes

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