Dimethylformamide → HCID 178433679, compound

HRID 26726Notes

Reaction equation

HRID 26726 reaction equation
[N:1]#[C:2][NH2:3].[Pb].[CH3:5][C:6]1[NH:10][CH:9]=[N:8][C:7]=1[CH2:11][S:12][CH2:13][CH2:14][NH:15][C:16](=S)[NH:17][CH2:18][CH2:19][CH2:20][NH:21][C:22]([NH:24][CH2:25][CH2:26][S:27][CH2:28][C:29]1[N:30]=[CH:31][NH:32][C:33]=1[CH3:34])=S.C[N:37]([CH3:40])C=O.C(#[N:43])C>>[C:2]([N:3]=[C:22]([NH:24][CH2:25][CH2:26][S:27][CH2:28][C:29]1[N:30]=[CH:31][NH:32][C:33]=1[CH3:34])[NH:21][CH2:20][CH2:19][CH2:18][NH:17][C:16]([NH:15][CH2:14][CH2:13][S:12][CH2:11][C:7]1[N:8]=[CH:9][NH:10][C:6]=1[CH3:5])=[N:43][C:40]#[N:37])#[N:1]

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 6342AcetonitrileHCID 22262466CH2N2PbHCID 537592711,3-bis-[N'-(2-(5-methyl-4-imidazolylmethylthio)ethyl)thioureido] propane

Product 1

HCID 178433679HCID 178433679, compound

Procedure

Lead cyanamide (3.0 g) was added to 1,3-bis-[N'-(2-(5-methyl-4-imidazolylmethylthio)ethyl)thioureido] propane (2.5 g) in acetonitrile. Dimethylformamide was added and the mixture was stirred and boiled under reflux for 24 hours. The mixture was filtered, concentrated and purified by chromatography to give the title compound.

Workup

  1. temperatureunder reflux for 24 hours
  2. filtrationThe mixture was filtered
  3. concentrationconcentrated
  4. custompurified by chromatography

Sources & evidence

ORD record
ord-1319bae13f4e405d82aec8648d270b48
Source dataset
uspto-grants-1979_04
Patent number
US04151289

Reaction notes

Loading…