反应详情

Lead cyanamide (3.0 g) was added to 1,3-bis-[N'-(2-(5-methyl-4-imidazolylmethylthio)ethyl)thioureido] propane (2.5 g) in acetonitrile. Dimethylformamide was added and the mixture was stirred and boiled under reflux for 24 hours. The mixture was filtered, concentrated and purified by chromatography to give the title compound.

1. temperatureunder reflux for 24 hours
2. filtrationThe mixture was filtered
3. concentrationconcentrated
4. custompurified by chromatography