Potassium Hydroxide → 4-Chloro-alpha-(2,6-difluorophenyl)-o-toluidine

HRID 267274Notes

Reaction equation

HRID 267274 reaction equation
[NH2:1][C:2]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:3]=1[C:4]([C:6]1[C:11]([F:12])=[CH:10][CH:9]=[CH:8][C:7]=1[F:13])=O.[OH-].[K+]>C(O)COCCO>[Cl:18][C:15]1[CH:14]=[C:3]([CH2:4][C:6]2[C:7]([F:13])=[CH:8][CH:9]=[CH:10][C:11]=2[F:12])[C:2](=[CH:17][CH:16]=1)[NH2:1]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 155638354-Chloro-2-(2,6-difluorobenzoyl)aniline

Product 1

HCID 214973734-Chloro-alpha-(2,6-difluorophenyl)-o-toluidine

Reagents, catalysts & solvents 1

HCID 8117Diethylene GlycolSolvent

Procedure

In the manner given in Preparation 11, 2-amino-5-chloro-2',6'-difluorobenzophenone is refluxed with potassium hydroxide in diethylene glycol to give 4-chloro-α-(2,6-difluorophenyl)-0-toluidene.

Workup

  1. customto give 4-chloro-α-(2,6-difluorophenyl)-0-toluidene

Sources & evidence

ORD record
ord-2d200cde9e4249eea56ca40279d1c944
Source dataset
uspto-grants-1976_03
Patent number
US03941802

Reaction notes

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