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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 267274Generated: October 29, 2026

Potassium Hydroxide → 4-Chloro-alpha-(2,6-difluorophenyl)-o-toluidine

https://huagongshe.com/reaction/267274

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium HydroxideHCID 14797—
Reactant4-Chloro-2-(2,6-difluorobenzoyl)anilineHCID 15563835—
SolventDiethylene GlycolHCID 8117—
Product4-Chloro-alpha-(2,6-difluorophenyl)-o-toluidineHCID 21497373—

Reaction Steps

In the manner given in Preparation 11, 2-amino-5-chloro-2',6'-difluorobenzophenone is refluxed with potassium hydroxide in diethylene glycol to give 4-chloro-α-(2,6-difluorophenyl)-0-toluidene.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS03941802
Source datasetuspto-grants-1976_03
ORD IDord-2d200cde9e4249eea56ca40279d1c944
Source noteuspto-grants-1976_03