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A solution of 28.0 g. (0.138 mole) of methyl γ-thiomorpholinobutyrate in 300 ml. of concentrated hydrochloric acid and 250 ml. of water was stirred and heated at reflux for 18 hours. The solvents were removed on a rotary evaporator to give a colorless residue which crystallized upon trituration with acetone. The solid was filtered, washed with acetone, and dried in vacuo to give 28.2 g. (91%) of the desired product as colorless crystals, m.p. 242°-245°C.

1. temperatureheated
2. temperatureat reflux for 18 hours
3. customThe solvents were removed on a rotary evaporator
4. customto give a colorless residue which
5. customcrystallized upon trituration with acetone
6. filtrationThe solid was filtered
7. washwashed with acetone
8. customdried in vacuo
9. customto give 28.2 g