Hydrochloric Acid → 2-Methyl-4-morpholinobutyric acid hydrochloride

Participants

Reaction Steps

32.0 g. (0.15 mole) of ethyl 2-methyl-4-morpholinobutyrate was combined with 200 ml. of concentrated hydrochloric acid and 200 ml. of water and refluxed with stirring for 20 hours. The solution was concentrated on a rotary evaporator to give a viscous, colorless residue. This material was triturated with acetone, filtered and dried to give 30.6 g. (92%) of colorless crystals, m.p. 155°-157°C.

Provenance & Evidence