Hydrochloric Acid → 2-Methyl-4-morpholinobutyric acid hydrochloride

HRID 267353Notes

Reaction equation

HRID 267353 reaction equation
[CH3:1][CH:2]([CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1)[C:3]([O:5]CC)=[O:4].[ClH:16]>O>[ClH:16].[CH3:1][CH:2]([CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1)[C:3]([OH:5])=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21418135Ethyl 2-methyl-4-morpholinobutyrate

Product 1

HCID 681179462-Methyl-4-morpholinobutyric acid hydrochloride

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

32.0 g. (0.15 mole) of ethyl 2-methyl-4-morpholinobutyrate was combined with 200 ml. of concentrated hydrochloric acid and 200 ml. of water and refluxed with stirring for 20 hours. The solution was concentrated on a rotary evaporator to give a viscous, colorless residue. This material was triturated with acetone, filtered and dried to give 30.6 g. (92%) of colorless crystals, m.p. 155°-157°C.

Workup

  1. concentrationThe solution was concentrated on a rotary evaporator
  2. customto give a viscous, colorless residue
  3. customThis material was triturated with acetone
  4. filtrationfiltered
  5. customdried
  6. customto give 30.6 g

Sources & evidence

ORD record
ord-8d555abda325407b9bc3c499a3791a6d
Source dataset
uspto-grants-1976_03
Patent number
US03941782

Reaction notes

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