反应详情

32.0 g. (0.15 mole) of ethyl 2-methyl-4-morpholinobutyrate was combined with 200 ml. of concentrated hydrochloric acid and 200 ml. of water and refluxed with stirring for 20 hours. The solution was concentrated on a rotary evaporator to give a viscous, colorless residue. This material was triturated with acetone, filtered and dried to give 30.6 g. (92%) of colorless crystals, m.p. 155°-157°C.

1. concentrationThe solution was concentrated on a rotary evaporator
2. customto give a viscous, colorless residue
3. customThis material was triturated with acetone
4. filtrationfiltered
5. customdried
6. customto give 30.6 g