Hydrochloric Acid → 5-Phenoxypyrimidin-4-amine--hydrogen chloride (1/1)

Participants

Reaction Steps

To a solution of 15.3 g. (0.082 mol) of 4-amino-5-phenoxy pyrimidine in 100 ml. of 5% methanol in ethyl acetate was slowly added an ethyl acetate solution saturated with HCl gas. The clear solution was heated on a steam bath to remove the methanol until the solution became slightly cloudy. Cooling gave 10.2 g. (55%) of white crystalline solid mp 220°-221°.

Provenance & Evidence