Hydrochloric Acid → 5-Phenoxypyrimidin-4-amine--hydrogen chloride (1/1)

HRID 267369Notes

Reaction equation

HRID 267369 reaction equation
[NH2:1][C:2]1[C:7]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][N:5]=[CH:4][N:3]=1.CO.[ClH:17]>C(OCC)(=O)C>[ClH:17].[NH2:1][C:2]1[C:7]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][N:5]=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 431947HCID 431947, compound

Product 1

HCID 215570745-Phenoxypyrimidin-4-amine--hydrogen chloride (1/1)

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a solution of 15.3 g. (0.082 mol) of 4-amino-5-phenoxy pyrimidine in 100 ml. of 5% methanol in ethyl acetate was slowly added an ethyl acetate solution saturated with HCl gas. The clear solution was heated on a steam bath to remove the methanol until the solution became slightly cloudy. Cooling gave 10.2 g. (55%) of white crystalline solid mp 220°-221°.

Workup

  1. temperatureThe clear solution was heated on a steam bath
  2. customto remove the methanol until the solution
  3. temperatureCooling
  4. customgave 10.2 g

Sources & evidence

ORD record
ord-be74497d859741cdb8ab2759fef1860c
Source dataset
uspto-grants-1976_03
Patent number
US03941889

Reaction notes

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