反应详情

A mixture of 90 parts of ethyl 4-(2-pyridinylamino)-1-piperidinecarboxylate, 90 parts of potassium hydroxide and 720 parts of 2-propanol is stirred and refluxed for 2 days. The reaction mixture is evaporated. 1000 Parts of water are added to the residue and the product is extracted with dichloromethane. The extract is dried, filtered and evaporated. The residue is crystallized from 2,2'-oxybispropane, yielding 13 parts of N-(4-piperidinyl)-2-pyridinamine.

1. temperaturerefluxed for 2 days
2. customThe reaction mixture is evaporated
3. addition1000 Parts of water are added to the residue
4. extractionthe product is extracted with dichloromethane
5. customThe extract is dried
6. filtrationfiltered
7. customevaporated
8. customThe residue is crystallized from 2,2'-oxybispropane