反应详情

To a solution of 0.144 moles of ethyl 2'-chloro-4-biphenylylglycolate dissolved in 220 ml. of isopropanol is added 38 g. (0.7 mole) of potassium hydroxide. This mixture is then heated at reflux temperature in a nitrogen atmosphere. The solution is concentrated in vacuo to a viscous oil, which is then dissolved in 500 ml. of water and filtered. The filtrate is acidified with 10% HCl and the precipitate is taken up in ether. The ether layer is dried, filtered and the filtrate concentrated to dryness. Recrystallization of residue from benzene-cyclohexane 1:1 gives 2'-chloro-4-biphenylylglycolic acid.

1. temperatureThis mixture is then heated
2. temperatureat reflux temperature in a nitrogen atmosphere
3. concentrationThe solution is concentrated in vacuo to a viscous oil, which
4. dissolutionis then dissolved in 500 ml
5. filtrationof water and filtered
6. dry with materialThe ether layer is dried
7. filtrationfiltered
8. concentrationthe filtrate concentrated to dryness
9. customRecrystallization of residue from benzene-cyclohexane 1:1