Hydrochloric Acid → HCID 21523009, compound

HRID 267385Notes

Reaction equation

HRID 267385 reaction equation
[Cl:1][CH:2]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[Cl:20])=[CH:10][CH:9]=1)[C:3]([O:5]CC)=[O:4].Cl>C(O)(=O)C>[Cl:1][CH:2]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[Cl:20])=[CH:10][CH:9]=1)[C:3]([OH:5])=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21556280HCID 21556280, compound

Product 1

HCID 21523009HCID 21523009, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 52.5 g. (0.167 moles) of ethyl α,2'-dichloro-4-biphenylylacetate and 160 ml. of glacial acetic acid containing 40 ml. of 37% hydrochloric acid is refluxed for 20 hours. The mixture is concentrated under reduced pressure to give a gummy residue. The latter material is dissolved in 300 ml. of n-hexane, washed with ice-cold water (100 ml. total), dried over sodium sulfate and filtered. The hexane is removed to give α,2'-dichloro-4-biphenylylacetic acid.

Workup

  1. additionA mixture of 52.5 g
  2. concentrationThe mixture is concentrated under reduced pressure
  3. customto give a gummy residue
  4. dissolutionThe latter material is dissolved in 300 ml
  5. washof n-hexane, washed with ice-cold water (100 ml. total)
  6. dry with materialdried over sodium sulfate
  7. filtrationfiltered
  8. customThe hexane is removed

Sources & evidence

ORD record
ord-3edeedd14c784cd6930ceb9c2463814b
Source dataset
uspto-grants-1976_03
Patent number
US03941821

Reaction notes

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