Isopropylamine → HCID 21556260, compound

HRID 267387Notes

Reaction equation

HRID 267387 reaction equation
[Cl:1][CH:2]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[Cl:20])=[CH:10][CH:9]=1)[C:3]([O:5]CC)=O.[CH:21]([NH2:24])([CH3:23])[CH3:22]>CCOCC>[CH:21]([NH:24][C:3](=[O:5])[CH:2]([C:8]1[CH:9]=[CH:10][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[Cl:20])=[CH:12][CH:13]=1)[Cl:1])([CH3:23])[CH3:22]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 21556280HCID 21556280, compound

Product 1

HCID 21556260HCID 21556260, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 5 g. (0.016 moles) of ethyl α, 2'-dichloro-4-biphenylylacetate and 5.5 ml. of anhydrous isopropylamine are stirred over Linde 4A molecular sieve for 16 hours at room temperature. The reaction mixture is taken up in ether and washed 3 times with 15 ml. of 10% hydrochloric acid. The ether layer is dried over sodium sulfate, filtered, and the ether is removed. The residue is triturated with n-hexane and the precipitate is collected to obtain N-isopropyl α, 2'-dichloro-4-biphenylylacetamide.

Workup

  1. additionA mixture of 5 g
  2. washwashed 3 times with 15 ml
  3. dry with materialThe ether layer is dried over sodium sulfate
  4. filtrationfiltered
  5. customthe ether is removed
  6. customThe residue is triturated with n-hexane
  7. customthe precipitate is collected

Sources & evidence

ORD record
ord-c69879375158492e9a8da039731c6b92
Source dataset
uspto-grants-1976_03
Patent number
US03941821

Reaction notes

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