反应详情

A mixture of 5 g. (0.016 moles) of ethyl α, 2'-dichloro-4-biphenylylacetate and 5.5 ml. of anhydrous isopropylamine are stirred over Linde 4A molecular sieve for 16 hours at room temperature. The reaction mixture is taken up in ether and washed 3 times with 15 ml. of 10% hydrochloric acid. The ether layer is dried over sodium sulfate, filtered, and the ether is removed. The residue is triturated with n-hexane and the precipitate is collected to obtain N-isopropyl α, 2'-dichloro-4-biphenylylacetamide.

1. additionA mixture of 5 g
2. washwashed 3 times with 15 ml
3. dry with materialThe ether layer is dried over sodium sulfate
4. filtrationfiltered
5. customthe ether is removed
6. customThe residue is triturated with n-hexane
7. customthe precipitate is collected