Isopropylamine → HCID 21556260, compound

Participants

Reaction Steps

A mixture of 5 g. (0.016 moles) of ethyl α, 2'-dichloro-4-biphenylylacetate and 5.5 ml. of anhydrous isopropylamine are stirred over Linde 4A molecular sieve for 16 hours at room temperature. The reaction mixture is taken up in ether and washed 3 times with 15 ml. of 10% hydrochloric acid. The ether layer is dried over sodium sulfate, filtered, and the ether is removed. The residue is triturated with n-hexane and the precipitate is collected to obtain N-isopropyl α, 2'-dichloro-4-biphenylylacetamide.

Provenance & Evidence