Sodium Iodide → Ethyl alpha-iodo-2'-chloro-4-biphenylylacetate

Participants

Reaction Steps

A mixture of 40.5 g. (0.1 moles) of ethyl α-bromo-2'-chloro-4-biphenylylacetate and 150 g. of sodium iodide in 1 liter of anhydrous acetone is refluxed for 4 hours. The reaction mixture is then evaporated to dryness and extracted with ether. The ether is then washed with water, dried and evaporated to dryness to obtain ethyl α-iodo-2'-chloro-4-biphenylylacetate.

Provenance & Evidence