Hydrochloric Acid → HCID 21522979, compound

HRID 267391Notes

Reaction equation

HRID 267391 reaction equation
Cl[CH:2]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:18])=[CH:8][CH:7]=1)[C:3]([OH:5])=[O:4].[SH-:19].[Na+].Cl>C(O)C>[SH:19][CH:2]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:18])=[CH:8][CH:7]=1)[C:3]([OH:5])=[O:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 28015Sodium hydrosulfideHCID 21523009HCID 21523009, compound

Product 1

HCID 21522979HCID 21522979, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 14 g. (.05 moles) of α, 2'-dichloro-4-biphenylylacetic acid and 5 g. of sodium hydrosulfide in 100 ml. of absolute ethanol and under a nitrogen atmosphere is stirred for 15 hours. The mixture is then acidified with 6 N hydrochloric acid. The solvent is removed in vacuo and the residue is extracted into ether, washed with water, saturated sodium chloride solution, dried and evaporated to dryness to obtain α-mercapto-2'-chloro-4-biphenylylacetic acid.

Workup

  1. additionA mixture of 14 g
  2. customThe solvent is removed in vacuo
  3. extractionthe residue is extracted into ether
  4. washwashed with water, saturated sodium chloride solution
  5. customdried
  6. customevaporated to dryness

Sources & evidence

ORD record
ord-2f9575af59b04be19350e0ff94d603af
Source dataset
uspto-grants-1976_03
Patent number
US03941821

Reaction notes

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