Formaldehyde → HCID 21555899, compound

HRID 267431Notes

Reaction equation

HRID 267431 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[CH:5][C:6]([N:17]2[CH:21]=[CH:20][N:19]=[CH:18]2)=[C:7]([CH:16]=1)[C:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:9].[CH2:24]=[O:25]>C1(C)C(C)=CC=CC=1>[F:23][C:2]([F:1])([F:22])[C:3]1[CH:4]=[CH:5][C:6]([N:17]2[CH:21]=[CH:20][N:19]=[C:18]2[CH2:24][OH:25])=[C:7]([CH:16]=1)[C:8]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)=[O:9]

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 21497361HCID 21497361, compound

Product 1

HCID 21555899HCID 21555899, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

In the manner given in Example 1, 5-(trifluoromethyl)-2-(imidazol-1-yl)benzophenone is heated in a bomb with paraformaldehyde in xylene to 140° C. to give 5-(trifluoromethyl)-2-[2-(hydroxymethyl)imidazol-1-yl]benzophenone.

Sources & evidence

ORD record
ord-7a3ca5e23d32456d83d98dd22f87de0a
Source dataset
uspto-grants-1976_03
Patent number
US03941803

Reaction notes

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