Hydrazine → 8-chloro-6-(o-chlorophenyl)-2-methyl-4H-imidazo[1,2-a][1,4]benzodiazepine

HRID 267448Notes

Reaction equation

HRID 267448 reaction equation
ClC1C=CC=CC=1C(=O)[C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[N:16]1[CH:20]=[C:19]([CH3:21])[N:18]=[C:17]1[CH2:22][N:23]1[C:27](=O)C2=CC=CC=C2C1=O.NN>C(O)C>[Cl:15][C:13]1[CH:14]=[CH:9][C:10]2[N:16]3[CH:20]=[C:19]([CH3:21])[N:18]=[C:17]3[CH2:22][N:23]=[C:27]([C:12]3[CH:11]=[CH:10][CH:9]=[CH:14][C:13]=3[Cl:15])[C:11]=2[CH:12]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 215558252',5-Dichloro-2-[4-methyl-2-(phthalimidomethyl)imidazol-1-yl]benzophenone

Product 1

HCID 127071318-chloro-6-(o-chlorophenyl)-2-methyl-4H-imidazo[1,2-a][1,4]benzodiazepine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 25, 2',5-dichloro-2-[4-methyl-2-(phthalimidomethyl)imidazol-1-yl]benzophenone in ethanol is heated with hydrazine to give 8-chloro-6-(o-chlorophenyl)-2-methyl-4H-imidazo[1,2-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-11714be9494e42f58eb070fafb2c7283
Source dataset
uspto-grants-1976_03
Patent number
US03941803

Reaction notes

Loading…