反应详情

N-(1,3-Dioxan-2-ylmethyl)-2,6-diethylaniline (25 grams), sodium bicarbonate (10 grams), dioxane (30 ml) and water (4 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer and thermometer. The mixture is cooled to a temperature of about 0°C and chloroacetyl chloride (15 grams) is added, with stirring, over a period of about 15 minutes. After the addition is completed stirring is continued for a period of about 1 hour. After this time ether (100 ml) is added to the mixture and the resulting solution is washed with water. The washed solution is then dried over anhydrous magnesium sulfate and stripped of solvents leaving a solid residue. The residue is recrystallized to yield the desired product N-α-chloroacetyl-N-(1,3-dioxan-2-ylmethyl)-2,6-diethylaniline.

1. customequipped with a mechanical stirrer
2. additionis added
3. additionAfter the addition
4. stirringis completed stirring
5. waitis continued for a period of about 1 hour
6. washthe resulting solution is washed with water
7. dry with materialThe washed solution is then dried over anhydrous magnesium sulfate
8. customleaving a solid residue
9. customThe residue is recrystallized