Pyrrolidine → HCID 68135941, compound

HRID 267482Notes

Reaction equation

HRID 267482 reaction equation
[CH3:1][C:2]([NH:8][C:9](=[O:14])[CH2:10][CH2:11][O:12][CH3:13])([CH3:7])[CH2:3][C:4](=O)[CH3:5].[NH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1.[H][H]>[Pt]=O.CO>[CH3:1][C:2]([NH:8][C:9](=[O:14])[CH2:10][CH2:11][O:12][CH3:13])([CH3:7])[CH2:3][CH:4]([N:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1)[CH3:5]

Participants

6

Reactant 3

HCID 31268PyrrolidineHCID 21514640HCID 21514640, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 68135941HCID 68135941, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent2×

Procedure

Following the procedure of Example 1, 20.1 grams (0.1 mole) of N-(1,1-dimethyl-3-oxobutyl)-3-methoxypropionamide is reacted with 10 grams (0.14 mole) of pyrrolidine in the presence of 0.3 gram of platinum oxide and 100 ml. of methanol. When hydrogen uptake has ceased, the methanol is stripped and the product, N-(1,1-dimethyl-3-pyrrolidylbutyl)-3-methoxypropionamide, is isolated as described in Example 1.

Sources & evidence

ORD record
ord-c5552b5c0ef1424cbdf6541c6345d1df
Source dataset
uspto-grants-1976_03
Patent number
US03943114

Reaction notes

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