Dimethylformamide → HCID 178422952, compound

HRID 267507Notes

Reaction equation

HRID 267507 reaction equation
Cl.[CH3:2][N:3]([CH3:21])[CH2:4][CH2:5][N:6]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([CH3:16])[N:14]=2)[C:9](=[O:17])[C:8]([C:18](O)=O)=[CH:7]1.[NH2:22][C:23]1[NH:27][N:26]=[N:25][N:24]=1.CN(C)[CH:30]=[O:31]>>[CH3:2][N:3]([CH3:21])[CH2:4][CH2:5][N:6]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([CH3:16])[N:14]=2)[C:9](=[O:17])[C:8]([CH2:18][C:30]([NH:22][C:23]2[NH:27][N:26]=[N:25][N:24]=2)=[O:31])=[CH:7]1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 131710088HCID 131710088, compoundHCID 178509299HCID 178509299, compound

Product 1

HCID 178422952HCID 178422952, compound

Procedure

1(2-Dimethylaminoethyl)-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid, hydrochloride (4.6 g) and N,N'-carbonyldiimidazole (2.75 g) in dimethylformamide (40 ml) were stirred and heated to 90° for 2 hours. 5-Amino-1H-tetrazole (1.45 g) was added and the mixture was heated to 40° and stirred for 36 hours. The solid was collected, m.p. 305°-307° (d). (30%).

Workup

  1. temperatureheated to 90° for 2 hours
  2. temperaturethe mixture was heated to 40°
  3. customThe solid was collected

Sources & evidence

ORD record
ord-008635b398824dc2bef098e992e91772
Source dataset
uspto-grants-1976_03
Patent number
US03943141

Reaction notes

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