2-Chlorobenzaldehyde → HCID 68127107, compound

HRID 267529Notes

Reaction equation

HRID 267529 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2Cl)[C:10]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:9]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[NH:8][C:7]=1[CH3:29])=[O:5])[CH3:2].[Cl:30]C1C=CC=CC=1C=O.C(OC(=O)CC(C(OCC)=O)=O)C.C(OC(=O)/C=C(\N)/C)C>C(O)C>[CH2:1]([O:3][C:4]([C:6]1[CH:11]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:30])[CH:13]=2)[C:10]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:9]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[NH:8][C:7]=1[CH3:29])=[O:5])[CH3:2]

Participants

6

Reactant 4

HCID 69962-ChlorobenzaldehydeHCID 66951Diethyl oxalacetateHCID 6437562-Butenoic acid, 3-amino-, ethyl ester, (2Z)-HCID 68127693HCID 68127693, compound

Product 1

HCID 68127107HCID 68127107, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the same way, 2-methyl-4-(2'-chlorophenyl)-1,4-dihydropyridine-3,5,6-tricarboxylic acid triethyl ester is prepared from 14 g of 2-chlorobenzaldehyde, 19 g of oxalacetic acid diethyl ester and 13 g of β-aminocrotonic acid ethyl ester in 60 ccs of ethanol.

Sources & evidence

ORD record
ord-82f43cff46cb4195b25e04c06798d61d
Source dataset
uspto-grants-1976_03
Patent number
US03943140

Reaction notes

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