反应详情

Sodium hydride, 50% (0.75 mole) is added in portions with stirring to 50 ml. of cooled absolute ethyl alcohol. After the evolution of hydrogen has subsided, 0.075 mole of 6,7-dihydroxy-5,6,7,8-tetrahydro-1-naphthol is added, followed by the dropwise addition of 0.075 mole of ethyl α-bromoisobutyrate. The reaction mixture is refluxed with stirring for 16 hours. The solvent is evaporated in vacuo, the residue taken up in water and extracted with chloroform. The chloroform extract is washed with water, dried and freed of solvent to give the title compound in the form of an oil.

1. temperatureThe reaction mixture is refluxed
2. stirringwith stirring for 16 hours
3. customThe solvent is evaporated in vacuo
4. extractionextracted with chloroform
5. extractionThe chloroform extract
6. washis washed with water
7. customdried