反应详情

is prepared by dissolving 10.4 grams (0.05 mol) of 3-(4-aminobenzenesulfonyl)acrylonitrile and 14 g (0.05 mol + 15% excess) of 4-hydroxy-3-carboxybenzenesulfonyl chloride in 200 ml acetone, cooling in an ice bath and slowly adding thereto 8 ml (0.055 mol) of triethylamine diluted with 25 ml acetone. After filtration and evaporation of the acetone the remaining semi-solid is dissolved in dimethylformamide, dispersed in water and the emulsion extracted with chloroform. After work-up the above sulfonamide is recovered.

1. customis prepared
2. temperaturecooling in an ice bath
3. additionslowly adding
4. filtrationAfter filtration and evaporation of the acetone the remaining semi-solid
5. dissolutionis dissolved in dimethylformamide
6. additiondispersed in water
7. extractionthe emulsion extracted with chloroform
8. customAfter work-up the above sulfonamide is recovered