反应详情

To a stirred solution of 4 parts of N-(4-chlorophenyl)-N-(4-piperidinyl)benzeneacetamide and 3 parts of N,N-dimethylethanamine in 200 parts of benzene are added portionwise 4 parts of 1-iodopropane and the whole is stirred and refluxed for 47 hours. Then the second portion of 4 parts of 1-iodopropane is added and stirring and refluxing is continued for another 20h.20. The reaction mixture is cooled and filtered. The filtrate is washed with water, dried and evaporated in vacuo. From the oily free base, the hydrochloride salt is prepared in the conventional manner in 1,1'-oxybisethane. The precipitated solid salt is filtered off and dried, yielding 3.5 parts of N-(4-chlorophenyl)-N-(1-propyl-4-piperidinyl)benzeneacetamide hydrochloride; mp. 235.5° C.

1. temperaturerefluxed for 47 hours
2. stirringstirring
3. temperaturerefluxing
4. temperatureThe reaction mixture is cooled
5. filtrationfiltered
6. washThe filtrate is washed with water
7. customdried
8. customevaporated in vacuo
9. filtrationThe precipitated solid salt is filtered off
10. customdried