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HRID267612

反应详情

EQUATION

反应方程式

HRID 267612 的结构方程式

REACTANTS

反应物

4
结构：CO
HCID887

Methanol

CH4O

结构：O
HCID962

Water

H2O

结构：O=S(=O)(O)O
HCID1118

Sulfuric acid

H2O4S

结构：CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@@H]5O[C@@H]5C[C@]4(C)[C@H]3C(=O)C[C@]12C
HCID86733130

未命名化合物

PRODUCTS

生成物

1
结构：CO[C@H]1C[C@@]2(C)[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(C)=O)[C@@]4(C)CC(=O)[C@@H]32)C[C@@H]1O
HCID86733129

未命名化合物

PROCEDURE

实验过程

2α,3α-Epoxy-5α-pregnane-11,20-dione (200 mg) was dissolved in dry methanol (20 ml), and concentrated sulphuric acid (0.1 ml.) was added. The solution was stirred at room temperature for 20 minutes, and then poured into water (125 ml.) to give a white crystalline precipitate which was filtered off and dried in vacuo over phosphorus pentoxide to give 3α-hydroxy-2β-methoxy-5α-pregnane-11,20-dione (175 mg.), m.p. 163°-164°, [α]D + 109°.

WORKUP

后处理

  1. customto give a white crystalline precipitate which
  2. filtrationwas filtered off
  3. dry with materialdried in vacuo over phosphorus pentoxide