Methanol → HCID 86733129, compound

Participants

Reaction Steps

2α,3α-Epoxy-5α-pregnane-11,20-dione (200 mg) was dissolved in dry methanol (20 ml), and concentrated sulphuric acid (0.1 ml.) was added. The solution was stirred at room temperature for 20 minutes, and then poured into water (125 ml.) to give a white crystalline precipitate which was filtered off and dried in vacuo over phosphorus pentoxide to give 3α-hydroxy-2β-methoxy-5α-pregnane-11,20-dione (175 mg.), m.p. 163°-164°, [α]D + 109°.

Provenance & Evidence