反应详情

Triethylamine (4.5 mmole) was added to a solution of 3α-hydroxy-5α-androstan-11-one 17β-carboxylic acid (1.025g.) in warm acetone (50 ml.) followed by chloroacetonitrile (6 mmole). After refluxing this mixture for 3 hr. further chloroacetonitrile (6 mmole) was added and refluxing continued for 4 hr. Removal of the solvent afforded a residue which was partitioned between ether and water. The ethereal solution was washed with water, dried (MgSO4) and evaporated, to give a foam (1.187g.) which was purified by preparative t.l.c. to afford the pure title compound; m.p. 142°-146°; [α]D + 74°,.

1. temperatureAfter refluxing this mixture for 3 hr
2. temperaturerefluxing
3. customRemoval of the solvent
4. customafforded a residue which
5. customwas partitioned between ether and water
6. washThe ethereal solution was washed with water
7. dry with materialdried (MgSO4)
8. customevaporated
9. customto give a foam (1.187g.) which
10. customwas purified by preparative t.l.c